Apixaban Tablets 5mg

Apixaban Tablets 5mg belong to a class of medications known as direct oral anticoagulants (DOACs) or factor Xa inhibitors. It is commonly prescribed to prevent and treat blood clots, particularly in patients with non-valvular atrial fibrillation, deep vein thrombosis (DVT), and pulmonary embolism (PE). It also plays a preventive role after knee or hip replacement surgery to reduce the risk of thromboembolic events.

Manufactured under stringent pharmaceutical standards, Apixaban offers a safe, effective, and convenient oral alternative to traditional anticoagulants like warfarin. It is widely recognized for its predictable pharmacokinetics and lower monitoring requirements.

Therapeutic Uses

Apixaban 5mg is indicated for:

• Stroke prevention in atrial fibrillation (AF): Reduces the risk of blood clots that can lead to stroke in patients with irregular heartbeats (non-valvular AF).

• Treatment of deep vein thrombosis (DVT): Helps dissolve blood clots in the deep veins, usually in the legs.

• Treatment of pulmonary embolism (PE): Prevents and treats life-threatening blood clots in the lungs.

• Prevention of recurrent DVT/PE: For patients at continued risk of clot formation.

• Post-surgical thromboprophylaxis: Often used after orthopedic surgeries to prevent clot formation.

Mechanism of Action

Apixaban directly inhibits Factor Xa, an essential enzyme in the coagulation cascade. By blocking Factor Xa, it prevents the conversion of prothrombin to thrombin — ultimately stopping the formation of fibrin clots. This targeted mechanism reduces clot formation without affecting platelets, resulting in fewer dietary and drug interactions compared to traditional anticoagulants like warfarin.

Dosage & Administration

• Usual Adult Dose:

  • Atrial Fibrillation: 5mg orally twice daily.

  • DVT/PE Treatment: 10mg twice daily for 7 days, then 5mg twice daily thereafter.

  • Post-Surgical Prevention: 2.5mg twice daily (not 5mg, but this product may be used in adjusted cases per physician guidance).

• Important Notes:

  • Should be taken at the same time every day.

  • Can be taken with or without food.

  • Do not stop abruptly without consulting a healthcare provider.

Key Benefits

• ✅ Fixed-dose regimen – no need for INR monitoring like warfarin.

• ✅ Lower risk of intracranial bleeding compared to traditional anticoagulants.

• ✅ Rapid onset of action (within 3–4 hours).

• ✅ Well tolerated in long-term use.

• ✅ Minimal food interactions.

Precautions & Warnings

• Renal Impairment: Dosage adjustment may be necessary in patients with kidney disease.

• Bleeding Risks: As with all anticoagulants, there is an increased risk of bleeding. Avoid if active bleeding is present.

• Surgery/Procedures: Discontinue prior to certain surgical procedures as directed by a healthcare provider.

• Pregnancy & Breastfeeding: Use only if clearly needed; consult your physician.

• Drug Interactions: Avoid use with other anticoagulants (e.g., warfarin, rivaroxaban), and monitor when used with NSAIDs, SSRIs, or antiplatelet drugs.

Possible Side Effects

Common side effects may include:

• Bleeding (minor or major)

• Nausea

• Bruising

• Low hemoglobin levels

Seek immediate medical attention if you experience signs of serious bleeding (e.g., coughing up blood, black/tarry stools, or unexplained bruising).

Storage Instructions

• Store at room temperature (15°C – 30°C).

• Keep away from direct sunlight and moisture.

• Keep out of reach of children.

FAQs

Q1: Can I stop Apixaban 5mg once I feel better?
A: No. Never stop this medication without consulting your doctor, as it may lead to increased risk of clotting or stroke.

Q2: Does it require blood test monitoring?
A: Unlike warfarin, Apixaban does not usually require routine INR monitoring.

Q3: Can I take it with food?
A: Yes, Apixaban can be taken with or without food.

Disclaimer

This product information is provided for educational purposes only and should not be considered medical advice. Always consult your healthcare provider before starting or changing any medication.