Naltrexone HCI And Bupropion HCI

Product Overview For Naltrexone HCI And Bupropion HCI

Naltrexone HCI And Bupropion HCI is a prescription medication primarily used as an adjunct for weight management in adults with obesity or overweight conditions when combined with a reduced-calorie diet and increased physical activity. It combines two active ingredients, Naltrexone Hydrochloride (HCI) and Bupropion Hydrochloride (HCI), which work together to support appetite control and promote weight loss. This medicine is intended for use under medical supervision and should be integrated into a comprehensive lifestyle modification program.

How It Works

The combination of Naltrexone HCI And Bupropion HCI targets appetite regulation through the central nervous system. Bupropion HCI, an atypical antidepressant, acts on neurotransmitters such as dopamine and norepinephrine to help reduce appetite and control cravings. Naltrexone HCI, an opioid receptor antagonist, helps modulate reward pathways in the brain, decreasing food-related pleasure signals. Together, these mechanisms contribute to reduced calorie intake and support weight management efforts.

Uses / Indications

Naltrexone HCI And Bupropion HCI is indicated as an adjunct therapy for:

• Adults with a body mass index (BMI) ≥30 kg/m² (obesity)

• Adults with a BMI ≥27 kg/m² (overweight) who also have weight-related medical conditions, such as hypertension, type 2 diabetes, or dyslipidemia

It is not intended for rapid or short-term weight loss and should be used as part of a comprehensive lifestyle program, including dietary changes and regular physical activity.

Composition

Each tablet of this combination medicine contains the following active ingredients:

• Naltrexone Hydrochloride (HCI) – an opioid receptor antagonist

• Bupropion Hydrochloride (HCI) – a norepinephrine-dopamine reuptake inhibitor (NDRI)

The medicine is available in oral tablet form, designed for controlled-release administration to maintain steady therapeutic levels.

Administration

Naltrexone HCI And Bupropion HCI should be taken orally, usually twice daily, following a gradual dose escalation as prescribed by a healthcare professional to reduce the risk of side effects. Patients should follow their doctor’s instructions closely, including timing with meals and adherence to the prescribed dosing schedule. Regular monitoring by a healthcare provider is recommended to assess treatment efficacy and safety.

Storage Instructions

• Store at room temperature, between 20°C to 25°C (68°F to 77°F)

• Keep away from excess heat, moisture, and direct sunlight

• Keep the medication out of reach of children and pets

• Do not use the medicine past the expiration date printed on the packaging

Important Information / Warning

• Naltrexone HCI And Bupropion HCI should only be used under the supervision of a qualified healthcare provider.

• It may not be suitable for individuals with a history of seizure disorders, uncontrolled hypertension, or certain psychiatric conditions.

• Patients should inform their doctor of all other medications they are taking to prevent potential interactions.

• Sudden discontinuation is not recommended; any changes should be guided by a healthcare professional.

• Common side effects may include nausea, headache, or insomnia; persistent or severe side effects should be reported promptly.

For further information about safe use, potential interactions, and patient support, visit MedlinePlus – Naltrexone and Bupropion.