Ivermectin 12 mg

Ivermectin 12 mg

Ivermectin 12 mg is a prescription antiparasitic medicine widely used in medicine to treat several parasitic infections in humans. Its active ingredient, ivermectin, belongs to a class of drugs known as avermectins, which are derived from the natural product of the soil bacterium Streptomyces avermitilis. Over the past few decades, ivermectin has become an essential tool in managing parasitic disease because of its effectiveness, generally favorable safety profile, and ease of administration.

Mechanism of Action

Ivermectin 12 mg works by targeting the nervous system of parasitic organisms. It binds selectively to glutamate-gated chloride channels found in the nerve and muscle cells of parasites. This increases the flow of chloride ions into the cells, resulting in hyperpolarization (increased electrical charge inside the cell) that ultimately causes paralysis and death of the parasite. Because these channels are more prevalent in parasites than in human cells, ivermectin can selectively affect parasites with minimal impact on human nerve and muscle function at therapeutic doses.

Medical Uses and Indications

Ivermectin 12 mg is used to treat several important parasitic infections:

1. Strongyloidiasis – A parasitic infection caused by Strongyloides stercoralis, which can lead to gastrointestinal and skin symptoms and may become life-threatening in immunocompromised individuals.

2. Scabies – A contagious skin condition caused by the mite Sarcoptes scabiei, characterized by intense itching and a rash. Ivermectin is especially useful in crusted (Norwegian) scabies or outbreaks where topical therapy alone may be insufficient.

3. Onchocerciasis (River Blindness) – In specific public health settings, ivermectin is used to reduce microfilariae levels in the skin, thereby reducing symptoms and transmission.

4. Other parasitic infections – In certain regions, other off-label parasitic diseases are treated under medical guidance.

The exact dose and duration depend on the specific condition being treated and the patient’s weight. Because of how ivermectin is dosed by weight, a 12 mg tablet is commonly used in adults and sometimes older adolescents.

Administration and Dosage

Ivermectin tablets are taken orally with water on an empty stomach or with a light snack, as determined by a healthcare provider. For many parasitic infections, a single dose or a short course is prescribed, but the regimen may vary based on the infection type, severity, and clinical guidelines.

Because ivermectin’s dosing depends on body weight, healthcare providers calculate the appropriate number of tablets to reach the correct mg/kg dose. It’s important to complete the course as directed and not adjust the dose without medical advice.

Benefits of Ivermectin 12 mg

• Effective against a broad range of parasites: Particularly those causing strongyloidiasis, scabies, and other nematode infections.

• Oral administration: Convenient dosing compared to some injectable antiparasitics.

• High efficacy: Most patients respond well when dosed appropriately under clinical supervision.

• Well-studied safety profile: Ivermectin has been used in millions of patients across global treatment programs.

Side Effects and Safety Profile

Ivermectin is generally well tolerated at recommended doses, but some side effects may occur. Most are mild and temporary, including:

• Nausea and mild gastrointestinal discomfort

• Dizziness or headache

• Fatigue

• Skin itching or rash (especially after scabies treatment as the infestation clears)

More serious adverse effects are uncommon at therapeutic doses but may include allergic reactions or neurologic symptoms. Seek medical advice if side effects are severe or persistent.

Precautions and Considerations

Before taking Ivermectin 12 mg, individuals should inform their doctor if they:

• Are pregnant or breastfeeding

• Have liver or kidney disease

• Are taking other medications that may interact with ivermectin

• Have a known allergy to ivermectin or related compounds

Ivermectin is not approved for the prevention or treatment of viral infections such as COVID-19 outside of clinical trials, and major health authorities do not recommend its use for COVID-19. Its approved uses remain focused on parasitic diseases where evidence supports efficacy and safety.

Storage Instructions

Store ivermectin tablets in a cool, dry place away from direct sunlight and moisture. Keep out of reach of children and pets.

For authoritative, medically reviewed information on ivermectin and its uses, visit the MedlinePlus drug information page:
https://medlineplus.gov/druginfo/meds/a612015.html